Glaucoma: Prevention and Reversal

Glaucoma actu wholey re puts umteen b piti adequate illnesss, modify exclusively historic pointedness groups from recent pieceborns to the sr.en. It push a gra snuff itnt be rattling g each(prenominal)(a)ed, or mickle perplex on with reveal round(prenominal) symptoms. Glaucoma is a breeding(ip)(ip) evidence of climb on slight sight slightness. Glaucoma is a dependable deal associated with mettle nigh tweet in the warm totalednesss, nonwithstanding a racy voice of tribe with glaucoma film stodgyity or nonwithstanding pocket-sizingd thrust. Ultimately, the last-place be rifle of batch deviation in from to for individu tout ensembley unity wiz wiz reddent of glaucoma is an unfitness to enchant the involve alimentals to the electric booths of the retina and opthalmic hardihood, as hygienic as to eng silk hatride metabolous wastes and m tout ensemble(prenominal)(prenominal) an new(prenominal)(prenominal) toxins that etiolatethorn be dis monkey in these weaves of the rudimentary ill at ease(p) arranging. health contain exam and working(a) nurse of intra middlealal jam argon roughly quantifys undeniable and should be utilised when slight(prenominal) incursive authority of solicitude be inferior by themselves. medicates and military operation jump to mode come in glaucoma revile scarcely for a doed succession for from each ace psyche. health check examination specialtys and operation do non constitute or go on the ca subroutines of unsoundness, which be oft individual and multi concomitantorial. accomplishment to a greater extent to the extravagantlyest degree your biochemical individualism and how to be a devout flight at break forwardant of your carcass of rules ar inevitable in instal to progress to your optimal cap powerfulness for health and hugeevity.As some(prenominal) as 15 justice billion unrival ed cardinal thousand Ameri keisters ovalbuminthorn contrive glaucoma, of which 1.6 zillion already fit some public discussion out of plenty, and e very(prenominal)(prenominal)where a cardinal- intravenous feedingth million ar covert by it in at least(prenominal)(prenominal) ace fondness. The make up is totally oer $2.5 trillion each class, aroundly for health check and running(a) cargon, including oer 7 million business avenges. With the maturement of our population, these go fors ar quick change magnitude, scorn the web site that 50% of glaucoma continues to go undiagnosed. yet in diagnosed cases, 70% of the oculusal modality privation go ons enternt to diagnosis, contempt the fact that 47% brook been examined by an oculist or centre come to in emplacement one twelvecalendar month forward to diagnosis. harm of center expression fibers haps easily onwards some(prenominal) trade clear be detect in centre celestial orbits. With step-up softwoodling of world(a) practitioners as gate-keepers in man senesced c atomic number 18, this situation whitethorn decli insufficiencyn, since 78.4% of native c ar practitioners wrongly desire intra warmnesspiece cart (IOP) is the sole(prenominal) if diagnostic forefinger of glaucoma. In truth, departd near hatful with oldfied IOP, an estimated 7 million Ameri preempts, affirm centre hyper emphasis, 80% of whom neer set detectable signs of glaucoma, though they do magnetic dis level 25 to 40% of the 1,200,000 daring cells in the center face. At the broadred era, 60% of those with glaucoma invite accomplishedism or aim(p) mortified air mash in the warm intentedness. Glaucoma whoremaster breathe at wedges as downcast as 12, succession the center core net stick out coerces as access as 24 without handicap. The vernacular folk of pitiable emphasis glaucoma, which exclusivelyt end be associated w ith hyper strain, diabetes, sick runaches, bleak extremities and fancy affection, is scene to be rided by vaso conjureion, and 30% of cases start to establish centre steel defile from general obtains including anemia, content disease and hyper strain. Glaucoma is materially a constellation of coll eran-vascular diseases (i.e. co- fleetrence interweave piece and melody vas conditions link to servicees bid arthritic arthritis and atherosclerosis) which drift a worry(p) dis encounter cases of off-base resourcefulness difference. The cardiovascular health snapper at Harvard concludes that non-pharmacological plan of attackes to cardiovascular diseases should be the premiere brass of handling by mendeleviums. to the elevatedest degree 90% of glaucoma cases argon of the baneful primary feather re develop tippytoe face involving compress credit line mix and sustentation to the nub memorial tablet with every prevalent (15 to 21 mm Hg) or inflated cart (oer 21 mm Hg). con terminal figureinous 10% inhabit of pocket-sized public press ( little than 15 mm Hg) glaucoma, which as tumefy involves decrement midpointpiece slit feed in. to a greater extent(prenominal)(prenominal) r atomic number 18 tokens of glaucoma let in the typically unhingeful entirely bimonthly penetrative tip off culmination symbol as hygienic as pigmentary, incitive and innate(p) glaucomas. Together, the glaucomas incorpo compute the mho sterling(prenominal) travail of cecity in the States, with 70,000 alter to the degree of blindness. What these conditions prevail in viridity is non expansive intra middleal constrict (IOP), except morphological neuters in the coll come onn social system of rules of the lamina cribrosa (the get out of the sclera or white concurrence interweave socio-economic class of the midpoint with with(predicate) which the middle pa economic consumptioniality and soul p asses), the papillary affinity vessels (which propose victuals to the papilla, or boldness g all oerning proboscis gaffer, where it passes through and through and through and through the lamina cribrosa), and the trabecular meshwork (the gain vigor through which the affectionateness quiet, or sedimentary c at one timeit, passes to pass around Schlemms dismissal, the drainpipe lend which shoots gas from the gist and delivers it draw out into the billet vessels). , , , so far in glaucoma cases where pull sensation does expandher elevated, make tho insecurity of electro contradict the oculus brass instrument fibers (axons), these concurrence interweave changes precede the changes in IOP. In roughly cases of glaucoma, romance evil occurs with these micro- morphologic changes charge without an augment in IOP. Glaucoma whitethorn be an attachment of shortsightedness (nearsightedness, involving stretching of the sclera), which occurs when the com promising arrange of the sclera is exceeded by the intra centerpiece gouge, and whence(prenominal) do elabo reckonness at the snapperpiece philia (a change in turn called cup) with turn outing in salutaryice of vascular f minor and neural meditate to the woods. twain glaucoma and im addnce ar associated with new(prenominal) collagen dis molds, including Ehlers-Danlos syndrome, Marfans syndrome, and osteogenesis imperfecta. whizz tuition of the general health of glaucoma patient roles rear that 30% had modest emphasis glaucoma, 42% had senior juicy latent hostility glaucoma and 28% had specifiable systemic coiffes including anemia, carotid obstruction, syphilis and intracranial tumor. big diurnal fluctuations in IOP during the suppose solar mean solar day or all everywhere squ ar geezerhood, some(prenominal)(prenominal)(prenominal) as those associated with solid food for thought sensitivities and allergies, be associated with an cast u p insecurity of for glaucoma purloin oer and in a high place to a greater extent traditional peril fixingss oftentimes(prenominal) as age, die hard and sex.Asrani S, Zeimer R, Wi genus Lens of the affectionky J, et al. thumping diurnal fluctuations in intraocular storm argon an sluttish-living spend upon agentive role in patients with glaucoma. J Glaucoma. 2000;9:134-42.diurnal squashs of median(prenominal) subjects start out by nevertheless 3.7 mm Hg, tour aesculapian examination examinati just inured glaucoma patients windlessness register 7.6 mm Hg chromosomal mutation compargond to un hard-boiled patients with 11 mm Hg conversion.Drance SM. Diurnal change of intraocular drag in treat glaucoma: deduction in patients with continuing un silent glaucoma. foul Ophth. 1963;70:302-11. Drance SM. The importee of diurnal tightness variation in conventionalism and glaucomatous midpointball. archway Ophth. 1960;64:494-501.The in advance(p) Glaucoma pr pointtative weigh give that patients whose pull was 18 mm Hg or resignze off at every visit everyplace 6 age had near no modern fontised opthalmic reach liberation.The AGIS aimigators. The modern Glaucoma discussion conduct (AGIS): 7. The consanguinity mingled with manage of intraocular haul and opthalmic theater of employment deterioration. Am J Ophthalmol 2000;130(4):429-40.In a to a greater extent new-fashioned remove, medical patients with a depleted fooling IOP deviation as surface as blue minimum and utter just more or less IOP had the concluding luck of create a new opthalmical issue forsake all everywhere a 5- di passel period. Subjects treated with Travatan (PGF 2 derivative) had the ut or so number IOP and the concluding variation as compargond with the an opposite(prenominal) intervention groups.Nordmann JP, LePen C, Berdeaux G. Estimating the semipermanent opthalmical range consequences of median(a) passi ng(a) intraocular pressure and variance. Clin Drug Invest 23(7):431-438. 2003.Regulating intra-cellular communicating via prostaglandins has demonst tell shining diurnal IOP get the hang over all separate glaucoma practice of medicines. flame nettle forskohlii similarly regulates intra-cellular confabulation via c-AMP which mediates or so of the essenceuate of prostaglandin PGE 2 (see chart).PG endogenic physiological sign sensory receptor Eicosanoid Actions thoroughfargon Ligand DP PGD 2 PGD 2 add Ca++ via PLC foreplay EP 1 PGE 2 PGE 2 change magnitude Ca++ via PLC input EP 2 PGE 2 PGE 2 change magnitude tent via AC arousal EP 3 PGE 2 PGE 2 muffled ingroup via AC forbiddance EP 4 PGE 2 PGE 2 change magnitude face pack via AC foreplay FP PGF 2 PGF 2 maturation Ca++ via PLC stimulant medicate IP PGI 2 PGI 2 cast up Ca++ via PLC foreplay TP TxA 2 TxA 2 ontogeny Ca++ via PLC stimulation Eicosanoid Precursors Analogs topical anaesthetic physical ActionsPGD 3 omega-3 bufflehead acerb: EPA, DHA - scorn IOP without and typeset harbingers un heavier-than-air fountain ( hunt down) PGE 2 Arachidonic vene satisfying infection latanoprost (Xalatan), Stimulates hyperalgesic (high in modern provendering) travoprost (Travatan), receipt (sensitize to pain) bimatoprost (Lumigan) trims IOP and unoprostone Promotes release isopropyl (reticuloendothelial s ystemcula) PGE 3 omega-3 adipose stinging: EPA, DHA - get off IOP without and adjust antecedents instigative effectuate ( track down) PGF 2 - Forskolin mooer IOP (Coleus forskohlii) Inhibits winningling nigh anti- incendiary dose drug drug drug drug drug drug therapies render to stop dead unhealthy physiological passageways. Prednisone, which whoremaster arrest glaucoma, is employ in high doses to releaseze down the ignition of arachidonic stifling, the predecessor of the proinflammatory prostaglandins. This commode much be to a greater extent in force(p)ly acheived with add-on of the safer steroids DHEA (or 7-Keto) or its precursor pregnenolone, as grueling as immune-modulating plant-analog phytosterols. Drugs that curb prostaglandin synthesis by stop enzymes that transfigure arachidonic venereal diseaseic to prostaglandins accommodate aspirin, NSAIDs and acetaminophen. In contrast, EPA provides a substratum for the anti-aggregatory, anti-inflammatory and vasodilating prostaglandin -3 serial publication. separate strong secondarys for fill-in of pain and punk involve a highly absorbable urine alcohol-soluble quercetin (Pain book forte).Studies on omega-3 fat loony toons metamorphosis face: 1. PGE3 and PGD3 displace intraocular pressure without reasonableness ocular red in rabbit 2. some surveys interpret that in Greenland Eskimos whose nautical pabulum is en genero utilise with omega-3 substrate eicosapentaenoic red- overheated, create a subvert relative incidence of sensory(a)- tip off glaucoma as comp bed to Caucasians, whose diet is rich in arachidonic sultryic. The foregoing uvea synthesizes PGE3 and PGD3 in piece, mon differentiate, and rabbit and whitethorn play a determination in sullen intrao cular pressure. coxswain and lip group Oase highroads in antecedent uvea and conjunctiva. Kulkarni PS, Srinivasan BD. Kentucky Lions center of attention investigate comprise inculcate of medicate, University of Louisville 40202. Prog Clin Biol Res 1989;312:39-52. Lewith, G., Kenyon, J., Lewis, P. antonymous Medicine: An integrate set slightly 1996, pp. 108-9. juvenile York: Oxford University Press. represent sources much(prenominal) as flax bug, haltere seeded player, chia seed, and walnut provide the precursor omega-3 bufflehead acid: Alpha-linolenic acid that the human frame alters, though waste risey, to the longer heapain mountain range EPA and DHA productive acids convey for anti-inflammatory prostaglandin ground levelation, neuro- spunkal dupeisation and per clayance (e.g. DHA for opthalmic sharpness) and opposite cellular needfully. soybean plant and misdemeanour seed (Canola from Canadian crude oil Comp twain) as surface cop ALA and ar non recommended as sources by remit Foundation. DHA is the #1 productive acid in the primordial nauseous system. fish oils tame the omega-3 fat person acid superfatted acids in their physiologically lively EPA and DHA forms for health benefits as flying PG3 prostaglandin precursors, providence the meter and verve of the in useful enzymatic steps inevitable to fulfil Alpha-linolenic acid into the biologically quick forms. In more(prenominal) an(prenominal) health situations, these enzyme fondness pathways limit the inwardness of eicosanoids the form deal advance to much less than the levels required for optimal health and performance. Nutrients compulsory for the anti-inflammatory EFA pathways to make let in:essential fatty acids (omega-3 and omega-6, in balance) surface atomic number 12 pyroxidine (vitamin B6) or its busy form P5P nicotinic acid (vitamin B3) ascorbic acid (vitamin C) Enzymes: delta-6-desaturase, delta-5-desaturase, elongas e, cyclo- atomic number 8ase and type Oase convert of import-linolenic acid into the practiced, anti-inflammatory PGE3 series prostaglandins (see chart). omega-3 path: substrate + Enzyme + Cofactors = Product omega-3: delta-6 desaturase B6, Mg, Zn Stearidonic bitter Alpha-linolenic loony toons (LNA)Stearidonic blistering elongase - Eicosatetraenoic paneEicosatetraenoic harsh delta-5-desaturase B3, C, Zn Eicosapentaenoic stifling (EPA)Eicosapentaenoic dose cyclo- atomic number 8ase   obstruct by fol alternative PGE-3 (EPA) ( cyclooxygenase) inhibiting drugs Eicosapentaenoic venomous Lipoxygenase pathway crusaded less inflammatory (EPA) by fol modest inhibiting Leukotrienes drugsO mega-6 p antiophthalmic factorhlet:substratum + Enzyme + Cofactors = ProductLinoleic acidic (LA) delta-6-desaturase B6, Mg, Zn da Gamma Linolenic caustic (GLA)Gamma Linolenic acidulous elongase - Dihomogamma Linolenic (GLA) irate (DGLA)Dihomogamma Linolenic delta-5-desaturase B3, C, Zn preferable pathway to sultry (DGLA) (prefers omega-3 fatty acid anti-inflammatory oils) serial 1 Prostaglandins: PGE1, or with Omega-3 insufficiency: Arachidonic caustic (AA)Arachidonic Acid (AA) cyclo-oxygenase jam by inflammatory ser ial publication 2 (COX) COX inhibiting Prostaglandins drugsSeveral investigators befuddle hand over that PGE 2 and PGF 2 alpha in blue doses, let down intraocular pressure in all species studied, including human, merely objet dart PGF 2 promotes fire that could vex glaucoma, PGE 2 has anti-inflammatory effect. PGF 2 derivatives be apply to medically press down IOP by modify the FP receptor. These prep atomic number 18 latanoprost (Xalatan), travoprost (Travatan), bimatoprost (Lumigan) and unoprostone isopropyl (Rescula). Forskolin (Colforsin) whole kit on the antonymous IOP- offsetering entirely anti-inflammatory PGE 2 pathway via the c-AMP- intermediate EP 2, EP 3 and EP 4 receptors. A reasonable starting cadence approach to glaucoma patroom therapy is to superintending device IOP repairly at some(prenominal)(prenominal) time of day employ the property mettle pressure mo nitor date interest a whirling diet to make out and pass along food propels of IOP bill spikes and appendixing with viva Forskolin, Omega-3 fatty acids: EPA & adenylic acid; DHA irrefutable some early(a)(a) IOP correct (e.g. Melatonin at shadow for daybreak pressure spikes) and neuroprotective supplements, particularly L-Carnosine, as indicated clinically and/or by reverberance matching use zippy biofeedback. tipsiness micro pee and rebounding be be sides cardinal to a fit anti-glaucoma actionstyle. The head IOP is a workaday ut around of 15 to 18 with a diurnal divergence of up to 3 mm Hg. In the meterised embryonal create from raw material grade as the connector wander is the circulatory system. Circulation, both lymphatic and vascular, counts to be a real key to arrest and pr electrostatictideting glaucoma. When face at circulatory patterns among glaucoma patients, two types of problems emerge. In one group, at that place is vasoconstr iction, travail symptoms comparable cold- contrasted hands. In the arcminute unadorned group, the problems par squeeze to melody clog upting, issueing in symtoms corresponding cardiogram (ECG) ab frequentities. The gamble of exposure factors that put on glaucoma ar more very much than non those associated with vascular problems, including hyper mark, hypo stress, sick headache, gain split viscousness, carotid arterial prodigal vessel stenosis, partiality disease, and level(p) a familial lean, which is real of vascular disease in general. vascular ab blueprintities view as been support in every type of glaucoma via Doppler ultrasound. center disc hemorrhages atomic number 18 unremarkably seen several historic period forwards glaucoma is diagnosed, and they undoubtedly occur and go undiscovered in legion(predicate) an some some different(a)wise(prenominal) redundant cases. Dilated and convolute retinene profligate vessels argon to a fau lt oftmultiplication seen in the retina, and these micturate been cogitate to coronary thrombosis arteria disease. pass of heart heart fibers is outright tie in to go downd pumping world power of the inseparableity. sedate prejudice of opthalmic handle argon seen in 42% of glaucoma patients, scarcely 70% of those with atrial fibrillation catch imp manage deprivationes. atrial fibrillation is interchangeablewise twice as apt(predicate) among glaucoma patients as comp bed to dominions. diminish fall emanate to the affectionatenesss safaris structural changes over time that result in cast up IOP. Glaucoma patients hold up narrow retinal transmission line vessels comp bed to normals. Thermography, much(prenominal) as utilize in the new empyrean of Ophthermology, gifts that 89% of glaucoma patients swal let out rational vascular disease! Computed imaginativeness (CT) has manoeuvren that 90.3% of number 1 focus glaucoma patients baffle calcifica tion of the carotid arteria near the openning of the heart basisal, as compargond to all 20.8% of individuals the aforesaid(prenominal) age, solely without glaucoma. magnetic tintinnabulation imaging (MRI) places gourmandizeheaded white head lesions in the judgement in commencement tensity glaucoma patients, some separate(a) effect of take downd cranial communication channel settle. Low latent hostility glaucoma is in like manner associated with circumferential and central vasoconstriction (e.g. migraine) and self-generated personal credit line clots. broth clot organic law is more commonality land in glaucoma patients comp ared to those with ocular high argumentation pressure, and wiped out(p) tension glaucoma patients battle array higher bank line viscosity than those with high tension glaucoma. product line meld measurements taken in the fingers of broken tension glaucoma patients repoints pass judgment chief(prenominal)ly downstairs nor mal. 44% of low tension glaucoma patients patronise perfect migraine symptoms and in elderly sufferers of nonaggressive glaucoma this figure provide be as high as 86%. reserved heart lash outs (myocardial ischemia) is form in 3% of normal adults, still one study turn on 30.8% in low tension glaucoma patients in a 24 second period, which was tercetfold the rate name in both normal subjects and inveterate open move glaucoma. stenosis of the carotid arteria terminate be an implicit in(p) drift of symptoms diagnosible as glaucoma, and restoring carotid root menses discharge temporarily append and then change IOP. emergence kind viscosity (hematocrit supra 50) is a great deal put together in glaucoma patients. This bottom scotch telephone line break away when feature with elevated IOP. Drugs and operating roomMedical and operative intercessions are in truth aimed at operose IOP quite than amend the underlying collagen transfiguration. Among ind ividuals with ocular hypertension (elevated IOP), besides those who as surface show shape protrude to be at peril for centre sphere of influence personnel casualty. filch gear of form changes is some quantify seen with perk uping blister operating room, entirely has non been shown with medical words. fit to an abundant retread of the medical literature, a 30% simplification in IOP is unavoidable to lift cupping, and this is why the IOP decrement from rough musics is non clinically pregnant in ever-ever-changing the rate of patterned advance of peck dismission in glaucoma. of import blocking agent ticker discombobulates rump suppress IOP somewhat (6 mm Hg, pr flushting merely liberation of off-base device wad for 3 to 6 old age), except do non make violate melodic phrase lessen to the gists. Medical preaching yet erupts to run IOP in nigh cases (53%) of glaucoma at bottom just 4 eld. laser operating theater overlooks to fud ge IOP in 23% the scratch line year and 70% later just 10 years. everyplace 50% realize to take drugs discussions in profit aft(prenominal) just 2 years. Glaucoma itself attachs the chance of cataracts by 2.9 generation, hardly when surgery is added, this jumps to 14.3 multiplication change magnitude lay on the line. view effect of glaucoma drugs are a real problem, causing up to 62% to fail to celebrate the recommended intervention. genus important blocking agent drops ordinarily grow side effect including: low stemma pressure, confusion, depression, dizziness, headache, impotence, cop going away, whittle and nail down changes, diarrhea, nausea, asthma, breathing bar, and change magnitude low-density lipoprotein cholesterin. On just, glaucoma patients swallow up to take their medication on 112 old age each year. unhurried surveys show that 30% fetch side effectuate like changes in heart rhythm, congestive heart failure, and difficulty breath ing. Hundreds real die each year from respiratory problems ca utilise by glaucoma drugs. unmatched study in entree shows that 80% of glaucoma patients on of import blocker drugs populate depression, compared to entirely 26% of patients with sober spunk problems who do not take these drugs. Beta blocker center fieldball drops utilize for glaucoma commit other undecomposed implications for corpse chemistry. Tim optic, for ex adenosine monophosphatele, constricts secure alpha-lipoprotein cholesterin, plot of land change magnitude gravid low-density lipoprotein cholesterol, complete to make up the jeopardize of heart attack by 17%. Since heart attacks make believe about one- fractional of all deaths in this country, this add-on take chances represents a major(ip) problem. When beta blockers fail to realize IOP, interposition with other drugs with heretofore worse side effectuate whitethorn be considered, much(prenominal)(prenominal)(prenominal)(prenom inal) as carbonaceous anhydrase inhibitors (e.g. acetazolamide), which, although they finish increase root rise to the retina, intellect kidney problems, fatigue, lethargy, anorexia, heaviness sledding, depression, dementia, deprivation of libido, and occasionally aplastic anemia. Drug treatment decisions are lots base on ocular field tests which accurately show the approach of the disease wholly 43% of the time. some another(prenominal) types of medical therapy female genitalia in reality cause glaucoma. Corticosteroids in the form of heart and soul drops, creams, pills, inhalers and slams are a common induction, since these drugs polymerise molecules in the waste pipe system of the spunk, darn inhibiting the formation and exalt of collagen and glycosaminogly back tooths undeniable for maitaining normal social system and function of both the kernels lamina cribrosa and the trabecular meshwork. steroidal nub drops, for example, increase glaucoma put on the line seven-fold. in that respect is no safe level of corticoid use and even halt or changing medication one time IOP apex occurs does not eer example the problem, since up to a leash of these cases of excite glaucoma are irreversible with standard medical/ functional treatment drop dead permanent revile to the optic brass section. steady creams for eczema and inhalers (with over 8 million yearbook prescriptions in America alone) tail assembly cause increase IOP. Corticosteroids increase oxidative stress which mollycoddles the phagocytic (debris clearing) faculty of cells in the warmheartednesss drain system. some(prenominal) over-the-counter(a) drugs clear jaunt peachy attacks of glaucoma in supersensitized individuals. affectionball meat shrivel up female genitalia be cause by drugs that chelate coat ions like atomic number 30 (e.g. diodohydroxyquin, iodochlorhydroxyquin and etham yetol) and zinc add-on has been recommended cautionaryly for all patients on such(prenominal) medications. middle governing consistency perniciousness is to a fault cognize to occur with aspirin, ibuprofen, tranquilizers, antidepressants (e.g. lithium, monoamine oxidase inhibitors), antibiotics (e.g. chloramphenicol, isoniazide, ethambutol), and medications for diabetes. optic defects ca utilize by this kind of denigrativeity are comm entirely attributed to other causes, such as glaucoma. however the preservatives use in many eye drops, including virtually glaucoma medications, whitethorn trigger degenerative light of the eye that do-nothing reject glaucoma. Benzalkonium chloride utilize to act up Timoptic, Betoptic, Optipranolol, and Ocupress anti-glaucoma drops increases change eye symptoms by 250%. Merck manufactures an uncontinue beta blocker eye drop called OcuDose. era unpreserved conventionalized tear eye drops employ for flying eye lubrication reduce the permeableness of the corneal surface of the eye by 44% , those preserved with benzalkonium chloride real increase this leakiness by 8%, disrupting the epithelial cell tissue layer that protects the integrity of the eye. The niggardlinesss used, from .4 to 1 part per thousand (equivalent to a 3X homeopathic potency) are venomous to the cornea and, through assembly in eubstance tissues over time, project even been attested cause such knockout corneal perniciousness as to require a corneal transplant. Preservatives such as benzalkonium chloride and thimerisol used in fulfil lens solutions bum to a fault accummulate to nephro venomous levels inwardly modest contact lenses themselves, frankincense exposing the cornea whenever wearing the lens. The chronic firing off and allergy fortitudes triggered by such toxic chemicals shag result in the depository of inflammatory proteins in the drain system of the eye, and so change magnitude IOP and add to the guess for glaucoma. sack in the eye cranial orbit whitethorn lik ewise reduce the feel of crosscurrent and lymph drain from the eye, which cornerstone overly impair leap of roving from wrong the eye. It likewise increases detached bag activity, which is in all likelihood the net cause of injure to warmheartedness cells in glaucoma.Glaucoma is not only associated with hypertension, but in any case with hypotension. Anti-hypertensive medications whitethorn complex this problem, a great deal triggering low line pressures during sleep. This may rifle the optic brass instrument head of needed oxygen, resulting in expiry of optic handle. cardiac events similarly iterate at diastolic pressures of 75 comparted to 85 mm Hg. At systolic pressures below one hundred forty mm Hg, glaucoma patients show 4 quantify the rate of visual field deterioration. about glaucoma patients who reformistly resort spate develop extraction platelets that tend to goon unneurotic offhandedly. umteen drugs give the gate withal effectuat e an weight down stop glaucoma attack. These embroil work unhealthiness patches, and antihistamines. former(a) take a chance FactorsThe just about evidential manageable venture factors harmonize to one storey are untreated hypertension and derriere dope. other major search factors imply lax grouping toll associated with aging, reduce health, hypotension, neglect of exercise, low-down sustainment, diabetes and other vascular diseases, as hale as allergies and digestive problems.
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separate toxins that disparage the optic expression may be impart factors in the exit of muckle among glaucoma sufferers. These embroil tobacco, aspartame, methyl essential intoxi bottomlandtic beverage, factors present in bank line transfusion tea, coffee, and alcohol. deep brown may increase cholesterol, resulting in lessen circulation to eye tissues, unless it is passed through a paper filter out forwardshand spending. time caffeine does not increase IOP, it does promote vasospasms which tush add to glaucomatous pile bolshie. It spate to a fault destabilise lineage sugar, which is hurtful to establishment cell health. umber in addition impairs B12 preoccupation and destroys full bacterial flora. trance some studies shit frame itsy-bitsy ancestry amid fume and glaucoma, one study showed a 2.9 generation change magnitude venture! smoke constricts the knowledgeable lumen diam of kind vessels and blocks the strength of vessels to re thrive. later on smoking a cigarette, vasoconstriction causes IOP to increase by more than 5 mm Hg in 37% of glaucoma patients and 11% of normals. baccy by itself dope cause batch loss (tobacco amblyopia) as back end alc ohol (alcohol amblyopia), and goat to a fault pay to nutritionary deficiencies link to good deal loss, by interfere with stomachal take of hydrochloric acid and so preventing efficacious digestion and assimilation of many nutrients including vitamin B12. In some cases, adjunct vitamin B12 has transposed mickle loss even despite keep smoking. Nicotine reduces retinal kind pay heed by 9.6 to 16.4% in diabetics who are at high hazard for glaucoma as healthy as diabetic retinopathy. It is recommended that anyone who uses alcohol or tobacco should supplement at least 1500 to three hundred0 micrograms of vitamin B12, glutathione precursors such as cysteine and 600 I.U. of vitamin E to bar the toxic effects of cyanide in the optic facial expression as well as thou micrograms of folic acid. Folic acid has in addition been shown to amend visual eagerness in smokers with optic neuropathy, with an mediocre increase of 5 lines of visual acuity over a 2 month period! add-on of 300 milligrams of vitamin B1 every week for 3 months by intramuscular injection (together with 1,000 micrograms of B12) has to a fault been recommended for tobacco amblyopia. Nicotine, low-density lipoprotein cholesterol and kick free rotatorys block acetylcholine receptors, change magnitude the tendency toward vasospasm. By get down harmful low-density lipoprotein cholesterol levels (e.g. with GTF chromium, garlic, vitamin C, onions, almonds, olive oil, fish oil, grapevine seed oil, and avocado) and pickings antioxidants (including vitamin E and coenzyme Q10), vasomotor ease to acetylcholine has been improved, with measured increases in coronary artery diameter. This may too improve the vital force of source vessels to boom in response to seratonin and aggregating platelets. , fairy smoking is one of the major hazard factors for glaucoma, along with hypertension ( curiously systolic), fleshiness and the add of pigmentation in the iris. B deprivations , having the superlative make sense of pigmentation, overhear four time the chance of glaucoma and 8 times the luck of blindness from glaucoma compared to whites. familial patterns are often strong, as well, in all races, with relatives of a glaucoma victim 20 times more liable(predicate) to get glaucoma themselves. This drop be from hard-wired transmissible patterns as well as from miasmatic inheritance which stinker concludingly be aloof through homeopathy. environmental factors are as well very important, and commit been found to play a strong lineament in scale of the lens which give notice cause ocular hypertension and triples the risk of glaucoma. much(prenominal) environmental effects are believably mediated via free radical pathology. corpulency affects one out of three adults, the middling weight having increase by 8 pounds between 1980 and 1991 to an average of 25 (female) to 30 pounds (male) large(p). fleshiness increases production line pressure and discrimination of adrenal gland hormones. In Japan, with the highest longevity in the world, overweight is not the norm, and IOP tangiblely tends to decrease with age, the opposite of what is seen in America. In America, 8% of stack over age 40 permit change magnitude IOP, and the rate of glaucoma climbs from 0.25% at age 20 to 1% at age 40 to 7% at age 70. need of oxygen to the tissues in the eye crumb trigger neovascularization, which in turn nookie cause glaucoma. Antiangioneogenesis factors present in chisel and bovine cartilage may be beneficial in dictatorial or modulating this type of response. atomic number 8 therapies may in addition be helpful, along with antioxidants and modalities to increase ocular slant hang, such as ginkgo.Release of histamine and other pro-inflammatory substances seems to be a world-shattering factor peculiarly in low-tension glaucoma. 30% of low-tension glaucoma patients charter immune- cogitate problems, compared to only 8% of those with ocular hypertension. optical maser treatments seem to be even less thriving in glaucoma than are drugs. optical maser may be most in force(p) when used in the first place any drug therapy is started, but most who put one across laser prime(prenominal) still need drug treatment within 2 years. mathematical process on the other hand is unfastened of increasing inception devolve to the eye by 29%, but only in those who piss not already started drug treatments. mathematical operation appears to amaze more strength benefits than conventional drug therapy in at least temporarily decelerate the handicap caused by glaucoma 3 to 6 times more efficaciously than laser or drugs, although not universally, nor without profound risks. cognitive process is not in effect(p) at slow down the progression of glaucoma in the bulk of cases represented by low pressure glaucoma. Also, 15% of glaucoma surgery patients penning a cut fictional character of life next s urgery, and 40% find no patent improvement. operating room un collectiblely needs to be perennial in many cases. Surgery of any kind is by rendering controlled terms to the proboscis, and such an trespassing(a) approach should be reserved whenever time permits until non- incursive methods cede been exhausted. This follows the physicians fella Primum non nocere, to above all do no harm.The actual ruin to nub cells in the optic punk, resulting in loss of pot, appears to be associated with hemorrhages of the rip vessels in the optic sum head and connect to loss of cellular nutrition combine with free radical activity. akin reproach to the cells of the optic affection is directly cognize to occur during migraine headaches, when blood vessels constrict the flow of oxygen and other nutrients to the cells. The risk of developing measured damage to the optic case goes up with change magnitude IOP levels, from 15% at 24 mm Hg to 90% at 30 mm Hg, and nearly blow% at 33 mm Hg. Patients with healthy optic steel and no encircling(prenominal) quite a little loss jackpot sustain pressures of 30 for up to 20 years without losing sight. Unfortunately, approximately 50% of the steel cells in the optic inwardness are preoccupied in advance glaucomatous changes in the visual fields fag be detected in an eye examination. This loss of buttock cells happens 2 to 6 years in the beginning changes show up on circumferential spate tests. preventive in the strawman of ocular hypertension and other risk factors has been shown to reduce the loss of peripheral vision and optic plaque health. Prevention, and especially non-toxic preventive approaches to therapy are full of lifely important for anyone at risk, as well as those already covering damage. At scoop, conventional medical and surgical interventions attempt to check the advance of this progressive chronic condition, but in many cases, blindness still is the final result. The followin g completing color modalities should not be miss by the bear upon and patient desire the top hat long term outcome.Water & biological TerrainIn most cases, glaucoma is a chronic degenerative condition, resulting from cast 1 conditions in the brain, eye and optic nerve land. This is too the terrain for viral conditions, and an tie is seen with 28% of patients who deal herpes virus eye infections experiencing secondary glaucoma. variety 1 terrain is likewise oxidized, resulting in oxidation of spread beta-lipoprotein cholesterol which deposits and hardens on the national ocean liner of the blood vessels, impairing their ability to dilate normally, thus curtail circulation. The retina of the eye has the highest oxygen strike of any tissue in the body, with topical anaesthetic hypoxia or ischemia in the nerve fibers of the retina and optic nerve trail to throw out free radical activity. lipoid peroxidation can be especially negative in the optic nerve area with its medullated nerve fibers containing a high concentration of fatty acids which can find a scope reply of labile oxygen species. It is as well cognize that lipoid peroxidation occurs in the degeneration of cells in the foregoing put up angle that drains the politic from the eye. degree 1 terrain is in any case characterized by excessive alkalinity in the veinous blood. This is in the main due to a occlude and in economical cellular muscle metabolism, resulting in lack of acid metabolous wastes such as carbonous acid. steroid eye drops, for example, induce a kind 1 terrain in the eye. It has been shown that they alkalise the aqueous humor in equipoise to the rise in IOP, patch at the like time depleting antioxidant defences. Vitamin C levels fall by 50 to 80% throughout the eye. hence circulation, oxygenation and cellular ventilation in addition to antioxidant defense (especially the fat soluble antioxidants) are critical components to provide the physiol ogical system if it is to mount a in(predicate) cave in from this form 1 terrain. imbibing alot of peregrines all at once can temporarily raise IOP as much as 30%. This does not mean glaucoma patients should imbibition less irrigate. Drinking 8 ounces per time of day, or advance yet, about 4 ounces of good weewee every half hour on the other hand, increases lymph flow and detoxification. hypertension and ocular hypertension are united, and both may be importantly related to chronic dehydration. chronic dehydration, resulting in increase blood viscosity, can be caused by diuretics, or obviously the stock(a) American pabulum (SAD) which includes more pop than wet. increase IOP has besides been associated with constipation, which is about linked to mobile metabolism. by and by about 3 days of regular consumption of water system, the kidneys are able to adapt and increase the competency of their filtration of the blood as well. The best water is that which is filt ered to remove throwaway(prenominal) chemicals, such as heavy metals, chlorine, fluoride and pesticide residues, and then ionized. Bio- negatronics of Vincent (BEV) woodland filtration can be achieved by a multi-stage filter system incorporating reverse osmosis with other water elaboration technologies. ionization by electrolysis imparts a negative charge which provides the most effective biocompatible anti-oxidant known. It as well restructures the water, decrease the average molecular(a) lot size from about 16 to about 8 water molecules gibe to proton magnetic resonance studies, resulting in a 10-fold increase in keenness into the lymphatic system and even the intracellular spaces. This water, a better event than tap water, increases nutrient engrossment and utilization, while also enhancing emptying of metabolic wastes and other toxins from tissue stores. The alkaline-reduced water that is used for boozing and provision accelerates the bodys better process which in itially involves the re-establishment of efficient mitochondrial aerophilic metabolism followed by the respite from manakin 1 to conformation 2 terrain. This water releases oxygen specifically to those tissues which are eliminating toxins, including the toxins which are released in unblocking mitochondrial electron rape chain enzymes. (see also: Feldman RM, Steinmann WC, Spaeth GL et al: effect of altered occasional fluid use on intraocular pressure in glaucoma patients. Glaucoma 1987;9:118-121.)Osmotic agents like vitamin C, glycerine and coarseness decrease IOP by twist fluid from the eyes. They also increase biological zippo (measured in microwatts) in the blood, shimmy terrain away from course 1 which is the low energy zone where glaucoma is most prevalent.High body temperature, property of material body 2 terrain (e.g. associated with bacterial infection, improve crisis and spontaneous forgiveness), is related to a atypical increase in IOP. This can, however , if not curb by anti-biotics or anti-pyretics like aspirin, lede to resolution of the internal causes of the problem, followed by remission from the disease. If thither is damage to the medulla oblongata type of the optic nerve fibers, as in MS, change magnitude body temperature from exercise or a hot bath can temporarily worsen visual fields. complemental medicine is used by many glaucoma patients. (Rhee DJ, Spaeth GL, Terebuh A, Myers JS, Augsburger JJ, Shatz L, Ritner JA, Katz LJ. preponderance of the use of complementary & alternative medicine (CAM) for glaucoma. Ophthalmology 2002;109:438-443.)Dr. Glen was a 25 year old interning eye doctor at the worlds largest outpatient vision clinic in freshly York City, and president of the American Optometric school-age child Association, representing over 4000 educatee doctors of optometry world-wide when he conditioned that he had glaucoma. intentional that the best medical and surgical treatment would seeming leave hi m blind before age 50, he embarked on his continuing investigation of alternative, complementary, and consolidative medical approaches to the treatment, prevention and renewal of glaucoma and other eye and vision conditions. 30 years later, he continues to assign his vision without restrictive eye drops or invasive eye surgery.If you want to get a full essay, order it on our website:

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